Compounding Bases

Spectrum Compounding Bases

Spectrum Pharmacy Products offers a new line of pharmaceutical bases to meet the unique needs of your patients and your formulations. Whether you are compounding for hormone replacement therapy, dermatology, veterinary applications or pain formulas, you can trust the performance of these high-quality bases from Spectrum. Our bases are designed for compounding efficiencies and high API loads. Most of the products are ready-to-use with no wetting required; this feature allows for active pharmaceuticals to be mixed directly into the cream bases, saving time and aiding effective formulation. The bases have undergone extensive performance and stability studies, all downloadable on the page below.

Spectrum has the right base to accommodate all concerns including skin type, sensitivities, and active ingredient compatibility. In addition to our new high-performance compounding bases, we continue to offer our Niosome-forming bases for enhanced absorption of commonly compounded APIs. Request your Free Base sample today! Ask your Sales Rep or call 800-370-6231.

Durabase Advanced Cream is a robust transdermal base that provides a cosmetically elegant, dry feel to the touch. The product is scientifically designed for broad API compatibility and solubility while being able to accommodate a wide pH range.

Durabase Cream is a versatile base with an elegant texture and broad uses. The product is designed for long shelf life and temperature stability, providing a superior alternative to PLO’s. Its broad API solubility and stability make it an excellent choice for a range of compounding formulations.

Lipocream Base is a heavy cream with additional emollients for moisturization of dehydrated skin. The product is scientifically designed for higher API loads and solvent concentrations, making it ideal for dermatology, pain, veterinary and sports medicine formulations.

Omnibase is an oil-free moisturizing base with enhanced, natural skin penetration designed to handle hydrophilic and lipophilic API’s. This cream is stable with a wide range of pH, capable of holding high salts and polar compounds and providing great flexibility for compounding formulations.

HRT Cream Botanical Base is a light weight cream that is designed for sustained skin penetrations and high lipophilic loads. This cream is formulated with natural ingredients, antioxidants, botanicals and herbal extracts, making it ideal for hormone replacement therapy.

HRT Cream Base is a heavy cream that is formulated from natural and paraben-free ingredients. The product is specifically designed for deeper skin penetration for male and female hormone replacement therapies, with stability and potency for all hormone API's.

Niosome Cream Base is a technology-enhanced transdermal base, promoting more rapid and extensive transdermal absorption than traditional liposomal bases. The product is designed with stable emulsion to protect from API degradation, and has a smooth, less greasy texture than liposome bases.

Niosome Cream Heavy Base is a technology-enhanced transdermal base, promoting more rapid and extensive transdermal absorption than traditional liposomal bases. The product is formulated for APIs with high molecular weight or in high concentrations, without reducing viscosity.

Niosome Hormone Cream Base is a technology-enhanced base designed for hormone therapy, being capable of promoting absorption of hormones/APIs that are lipophilic, hydrophilic or amphiphilic. The product's hypoallergenic formulation contains no perfumes, dyes or parabens.

Niosome Hormone Cream Heavy Base is a technology-enhanced base designed for hormone therapy, beingcapable of promoting absorption of hormones/APIs that are lipophilic, hydrophilic or amphiphilic. The product's hypoallergenic formulation contains no perfumes, dyes or parabens. This base is able to deliver high concentrations of API's, permitting low volume administration.

What is your application?

Applications/Properties	Pain	Sports	Dermatology	Veterinary	BHRT
Durabase Advanced Cream	✔	✔		✔
Durabase Cream	✔	✔		✔
Lipocream Base	✔	✔	✔	✔
Omnibase	✔	✔	✔	✔	✔
HRT Cream Botanical Base					✔
HRT Cream Base					✔
Niosome Cream Base	✔	✔	✔	✔
Niosome Cream Heavy Base	✔	✔	✔	✔
Niosome Hormone Cream Base			✔		✔
Niosome Hormone Cream Heavy Base			✔		✔

Why Choose Durabase Advanced Cream?

Increased stability with a high percent of APIs & multiple actives
Validated in vitro transdermal vehicle up to 8 APIs in one formulation
Less sticky & less tacky because of silogel (silicone-based organogel)
Off-white, cosmetically elegant cream
API compatibility – compatible with all actives, non-specific to salt
Time saving – ready-to-use base, no need for wetting or adding thickening agents
Ideal for formulations with multiple actives & high API loads

Durabase Advanced Cream Properties:

pH	7.1 - 7.5
pH Compatibility	Broad Range
Specific Gravity	0.90 g/mL
Viscosity	1,200,000 cps
Physical Format	Heavy Cream
Color	Off White
Transdermal Penetration	++++
API Compatibility	Hydrophilic 30% & Lipophilic 40% - Total API Load - 40%
Typical Applications	Pain Management, Sports Medicine, Veterinary Medicine

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Why Choose Durabase Cream?

Efficacious active drug absorption
In vitro transdermal penetration & API compatibility
Temperature stable & shelf stable
Hydrophilic compatibility – high levels of ionic powders can be directly incorporated
Lipophilic compatibility – moderate levels of oil-soluble powders can be levigated with glycerin, propylene glycol, polyethylene glycol (PEG) 300 or 400, or alcohol
Cosmetically elegant – not tacky or sticky
Natural ingredients – resulting in less irritation

Durabase Cream Properties:

pH	7.0
Specific Gravity	1.00 g/mL
Viscosity	300,000 cps
Physical Form	Heavy Cream
Color	Light Beige
Transdermal Penetration	++++
API Compatibility	Hydrophilic 35% & Lipophilic 10% - Total API Load - 35%
Typical Applications	Pain Management, Sports Medicine, Veterinary Medicine

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Why Choose Lipocream Base?

Cosmetically elegant – excellent moisturizing effect
Faster absorption & deeper penetration than HRT bases
API compatibility – virtually all actives Natural preservatives
Water & oil-soluble
Ideal for cosmetic facial applications
Paraben-free, fragrance-free and dye-free

Lipocream Base Properties:

pH	6.0
Specific Gravity	1.00 g/mL
Viscosity	250,000 cps
Format	Heavy Cream
Color	White
Natural Ingredients	Yes
Transdermal Penetration	++++
API Compatibility	Hydrophilic 10% & Lipophilic 10% - Total API Load 20%
Typical Applications	Dermatology, Pain Management, Immunotherapy, Sports Medicine
Recommended Use	Higher API Loads, Dry/Dehydrated Skin, Chemical Peels, Pigmentation Treatments

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Why Choose Omnibase?

Mineral oil-free, gluten-free, and propylene glycol-free
Noncomedogenic
Enhanced drug absorption & penetration
Ideal for topical & vaginal preparations
Stable over a broad range pH
API compatibility – hydrophilic & lipophilic
Natural ingredients – moisturizers derived from berries, grapes, plums, and pears & emulsifiers derived from vegetable fatty acids & palm oil; thickening agents derived from coconut oil

Omnibase Properties:

pH	7.0
Specific Gravity	0.90 g/mL
Viscosity	250,000 cps
Physical Format	Heavy Cream
Color	White
Transdermal Penetration	++
API Compatibility	Hydrophilic 10% & Lipophilic 20% - Total API Load - 30%
pH Compatibility	3.0-11.0
Salt Tolerance	Salt Forms - 10%
Solvent Compatibility	Polar & Non-polar
Typical Applications	Hormone Replacement (topical & vaginal), Dermatology, Pain Management, Sports Medicine

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Why Choose HRT Cream Botanical Base?

Sustained skin penetration and absorption
Paraben-free, fragrance-free and dye-free
Natural ingredients & natural preservatives
Added antioxidants, botanicals, and herbal extracts
Certified hypoallergenic
Cosmetically elegant
Ideal for topical or vaginal preparations

HRT Cream Botanical Base Properties:

pH	6.5
Specific Gravity	1.00 g/mL
Viscosity	60,000 cps
Physical Format	Light Cream
Color	Light Beige
Natural Ingredients	Yes
Transdermal Penetration	++
API Compatibility	Lipophilic 20%
Typical Applications	Hormone Replacement

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Why Choose HRT Cream Base?

Sustained skin penetration and absorption
Paraben-free, fragrance-free and dye-free
Natural ingredients & natural preservatives
Certified hypoallergenic
Cosmetically elegant
Ideal for topical or vaginal preparations
Stability/potency of 180 days for common hormone API's

HRT Cream Base Properties:

pH	7.5
Specific Gravity	1.04 g/mL
Viscosity	165,000 cps
Physical Format	Cream
Color	White
Natural Ingredients	Yes
Transdermal Penetration	+++
API Compatibility	Lipophilic 40%
Typical Applications	Hormone Replacement

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Why Choose Niosome Cream Base?

Smooth Texture and provide less oily feel than liposomes
Enhanced rate and extent of adsorption of common API's
Capable of entrapping hydrophilic, lipophilic and amphiphilic API's in the Niosome

Niosome Cream Base Properties:

pH	4.0 – 8.0
Specific Gravity	0.90-1.10 g/mL
Viscosity	60,000 cps
Physical Format	Light Cream
Color	Off-White
Transdermal Penetration	++++
API Compatibility	Hydrophilic 10%, Lipophilic 10%, Amphiphilic 10% Total API Load 20%
Typical Applications	Dermatology, Pain Management, Sports Medicine, Veterinary Medicine

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Why Choose Niosome Cream Heavy Base?

Higher API loads and solvent concentrations
Enhanced rate and extent of adsorption of common API's
Smooth and less oily than liposomes
Capable of entrapping hydrophilic, hydrophobic and amphiphilic APIs in the Niosome

Niosome Cream Heavy Base Properties:

pH	4.0 – 8.0
Specific Gravity	0.90-1.10 g/mL
Viscosity	110,000 cps
Physical Format	Heavy Cream
Color	Off-White
Transdermal Penetration	++++
API Compatibility	Hydrophilic 30%, Lipophilic 40%, Amphiphilic 30% Total API Load 40%
Typical Applications	Dermatology, Pain Management, Sports Medicine, Veterinary Medicine

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Why Choose Niosome Hormone Cream Base?

Contains no perfumes or dyes
Paraben free
Sustained transdermal penetration of lipophlic, hydrophilic and amphiphilic APIs
Ideal for vaginal preparations

Niosome Hormone Cream Base Properties:

pH	4.0 – 8.0
Specific Gravity	0.90-1.10 g/mL
Viscosity	9,000 cps
Physical Format	Light Cream
Color	Off-White
Transdermal Penetration	+++
API Compatibility	Lipophilic 20%, Hydrophilic 10%, Amphilphilic 10% Total API Load 20%
Typical Applications	Hormone Replacement, Dermatology

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Why Choose Niosome Hormone Cream Heavy Base?

Higher API loads and solvent concentrations
Contains no perfumes or dyes
Paraben free
Sustained transdermal penetration of lipophlic, hydrophilic and amphiphilic APIs
Ideal for vaginal preparations

Niosome Hormone Cream Base Properties:

pH	4.0 – 8.0
Specific Gravity	0.90-1.10 g/mL
Viscosity	110,000 cps
Physical Format	Heavy Cream
Color	Off-White
Transdermal Penetration	+++
API Compatibility	Hydrophlic 30%, Lipophilic 40%, Amphiphilic 30% Total API Load 40%
Typical Applications	Hormone Replacement, Dermatology